Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype

Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype

Abstract Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are characterised by increased α-smooth muscle actin (α-SMA) fibre expression, secretion of collagens and...

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Bibliographic Details
Main Authors: Caitlin Hall, Jonathan P. Law, Jasmeet S. Reyat, Max J. Cumberland, Shaun Hang, Nguyen T. N. Vo, Kavita Raniga, Chris J. Weston, Christopher O’Shea, Jonathan N. Townend, Katja Gehmlich, Charles J. Ferro, Chris Denning, Davor Pavlovic
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39369-y

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https://doi.org/10.1038/s41598-023-39369-y

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