MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.

Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I. Lack of MARCH1 in B cells and dendritic cells (DCs) resulted...

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Bibliographic Details
Main Authors: Kayla R Wilson, Haiyin Liu, Geraldine Healey, Vivian Vuong, Satoshi Ishido, Marco J Herold, Jose A Villadangos, Justine D Mintern
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6042767?pdf=render

Internet

http://europepmc.org/articles/PMC6042767?pdf=render

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