MicroRNA-29a-3p prevents Schistosoma japonicum-induced liver fibrosis by targeting Roundabout homolog 1 in hepatic stellate cells

MicroRNA-29a-3p prevents Schistosoma japonicum-induced liver fibrosis by targeting Roundabout homolog 1 in hepatic stellate cells

Abstract Background Schistosomiasis is a serious but neglected parasitic disease in humans that may lead to liver fibrosis and death. Activated hepatic stellate cells (HSCs) are the principal effectors that promote the accumulation of extracellular matrix (ECM) proteins during hepatic fibrosis. Aber...

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Bibliographic Details
Main Authors: Hongyan Kong, Qiqin Song, Wenjiang Hu, Shusen Guo, Dandan Xiang, Shuaiwen Huang, Xin Xu, Jinan He, Lanyue Pan, Ran Tao, Haijing Yu, Jiaquan Huang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Parasites & Vectors
Subjects:
microRNA-29a-3p
Roundabout homolog 1
Schistosoma japonicum
Hepatic fibrosis
Hepatic stellate cells
Therapy
Online Access:https://doi.org/10.1186/s13071-023-05791-4

Internet

https://doi.org/10.1186/s13071-023-05791-4

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