A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma

A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma

BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC). Based on the analysis of genomic profiles in H295R ACC cells, Mohan et al...

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Bibliographic Details
Main Author: Enzo Lalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Endocrinology
Subjects:
adrenocortical carcinoma
beta-catenin
nuclear receptors
transcriptional regulation
genomics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1303332/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1303332/full

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