A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma
BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC). Based on the analysis of genomic profiles in H295R ACC cells, Mohan et al...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-12-01
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Series: | Frontiers in Endocrinology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1303332/full |