Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder

Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder

Mithramycin (MTR) is a clinically approved DNA-binding antitumor antibiotic currently in Phase 2 clinical trials at National Institutes of Health for treatment of osteosarcoma. In view of the resurgence in the studies of this generic antibiotic as a human medicine, we have examined the binding prope...

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Bibliographic Details
Main Authors: Amrita Banerjee, Sulagna Sanyal, Kirti K. Kulkarni, Kuladip Jana, Siddhartha Roy, Chandrima Das, Dipak Dasgupta
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Mithramycin
Core histones
Dual binding mode
Epigenetic modulator
H3K18 acetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000965

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http://www.sciencedirect.com/science/article/pii/S2211546314000965

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