A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling

Introduction: Adult hippocampal neurogenesis (AHN) is acknowledged to play a critical role in depression. Emerging evidence suggests that the Wnt/β-catenin pathway can modulate hippocampal neurogenesis. Crocin, a natural carotenoid, possesses antidepressant property. Yet, how it affects neurogenesis...

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Bibliographic Details
Main Authors: Weiwei Tao, Jie Ruan, Ruyan Wu, Min Zhao, Tong Zhao, Mingming Qi, Sonata S.Y. Yau, Guangda Yao, Hongru Zhang, Yue Hu, Gang Chen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Advanced Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222000595