Synthesis, Biological Evaluation and Machine Learning Prediction Model for Fluorinated <i>Cinchona</i> Alkaloid-Based Derivatives as Cholinesterase Inhibitors

Synthesis, Biological Evaluation and Machine Learning Prediction Model for Fluorinated <i>Cinchona</i> Alkaloid-Based Derivatives as Cholinesterase Inhibitors

A series of 46 <i>Cinchona</i> alkaloid derivatives that differ in positions of fluorine atom(s) in the molecule were synthesized and tested as human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. All tested compounds reversibly inhibited AChE and BChE in the na...

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Bibliographic Details
Main Authors: Alma Ramić, Ana Matošević, Barbara Debanić, Ana Mikelić, Ines Primožič, Anita Bosak, Tomica Hrenar
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
<i>Cinchona</i> alkaloid derivatives
cholinesterase inhibitors
multivariate linear regression models
Online Access:https://www.mdpi.com/1424-8247/15/10/1214

Internet

https://www.mdpi.com/1424-8247/15/10/1214

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