Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

The M gene segment of influenza A virus has been shown to be a contributing factor to the high growth phenotype. However, it remains largely unknown why matrix protein 1 (M1), the major structural protein encoded by M gene, exhibits pH-dependent conformational changes during virus replication. Under...

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Bibliographic Details
Main Authors: Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier, Bashayer Althufairi, Zhiping Ye, Qibing Zhou, Umesh R Desai, Hang Xie, Martin K Safo
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Emerging Microbes and Infections
Subjects:
conformational change
influenza A virus
matrix protein 1
pH dependent
protein structure
virus replication
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2017.96

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https://www.tandfonline.com/doi/10.1038/emi.2017.96

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