CDR1as regulates α-synuclein-mediated ischemic brain damage by controlling miR-7 availability

CDR1as regulates α-synuclein-mediated ischemic brain damage by controlling miR-7 availability

Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of its major target α-synuclein (α-Syn) that promotes secondary brain damage. Circular RNA CDR1as is known to regulate miR-7 abundance and function. Hence, we currently evaluated its functional significance after f...

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Bibliographic Details
Main Authors: Suresh L. Mehta, Anil K. Chokkalla, Saivenkateshkomal Bathula, Vijay Arruri, Bharath Chelluboina, Raghu Vemuganti
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Noncoding RNAs
ischemia
α-synuclein
motor function recovery
pathological changes
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122003146

Internet

http://www.sciencedirect.com/science/article/pii/S2162253122003146

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