Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense

Summary: Recurrent epidemics of drug-resistant Staphylococcus aureus illustrate the rapid lapse of antibiotic efficacy following clinical implementation. Over the last decade, community-associated methicillin-resistant S. aureus (MRSA) has emerged as a dominant cause of infections, and this problem...

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Bibliographic Details
Main Authors: Corey P. Parlet, Jeffrey S. Kavanaugh, Heidi A. Crosby, Huzefa A. Raja, Tamam El-Elimat, Daniel A. Todd, Cedric J. Pearce, Nadja B. Cech, Nicholas H. Oberlies, Alexander R. Horswill
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719303250