Inhibition of miR-222 by Oncolytic Adenovirus-Encoded miRNA Sponges Promotes Viral Oncolysis and Elicits Antitumor Effects in Pancreatic Cancer Models

Inhibition of miR-222 by Oncolytic Adenovirus-Encoded miRNA Sponges Promotes Viral Oncolysis and Elicits Antitumor Effects in Pancreatic Cancer Models

Oncolytic adenoviruses (OA) are envisioned as a therapeutic option for patients with cancer, designed to preferentially replicate in cancer cells. However, the high number of genetic alterations in tumors can generate a context in which adenoviruses have difficulties replicating. Abnormal miRNAs exp...

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Bibliographic Details
Main Authors: Giulia Raimondi, Sabrina Gea-Sorlí, Marc Otero-Mateo, Cristina Fillat
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
miRNAs
oncolytic adenovirus
virotherapy
pancreatic cancer
miRNA-sponges
Online Access:https://www.mdpi.com/2072-6694/13/13/3233

Internet

https://www.mdpi.com/2072-6694/13/13/3233

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