Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression

<p>Abstract</p> <p>Background</p> <p>A high proliferative capacity of tumor cells usually is associated with shortened patient survival. Disruption of the RB pathway, which is critically involved in regulating the G1 to S cell cycle transition, is a frequent target of o...

Full description

Bibliographic Details
Main Authors: Hanamura Ichiro, Zhan Fenghuang, Zingone Adriana, Raducha-Grace Laura, Peterson Timothy R, Dib Amel, Barlogie Bart, Shaughnessy John, Kuehl W Michael
Format: Article
Language:English
Published: BMC 2006-10-01
Series:Cell Division
Online Access:http://www.celldiv.com/content/1/1/23