α-Hemihydrate calcium sulfate/n-hydroxyapatite combined with metformin promotes osteogenesis in vitro and in vivo

α-Hemihydrate calcium sulfate/n-hydroxyapatite combined with metformin promotes osteogenesis in vitro and in vivo

This study aimed to examine the effects of loading different concentrations of metformin onto an α-hemihydrate calcium sulfate/nano-hydroxyapatite (α-CSH/nHA) composite. The material characteristics, biocompatibility, and bone formation were compared as functions of the metformin concentration. X-ra...

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Bibliographic Details
Main Authors: Sirui Liu, Haojie Fu, Yan Lv, Jing Jiao, Runying Guo, Yanyu Yang, Wenhang Dong, Hongyan Mi, Meiyue Wang, Mengzhe Liu, Rui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
metformin
osteogenic differentiation
BSP
RUNX2
Opn1
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.899157/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.899157/full

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