Tandem Pd-Catalyzed Cyclization/Coupling of Non-Terminal Acetylenic Activated Methylenes with (Hetero)Aryl Bromides

Tandem Pd-Catalyzed Cyclization/Coupling of Non-Terminal Acetylenic Activated Methylenes with (Hetero)Aryl Bromides

We report a new method for a tandem Pd-catalyzed intramolecular addition of active methylene compounds to internal alkynes followed by coupling with aryl and heteroaryl bromides. Highly substituted vinylidenecyclopentanes were obtained with good yields, complete selectivity, and excellent functional...

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Bibliographic Details
Main Authors: Aleksandra Błocka, Wojciech Chaładaj
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
palladium
homogeneous catalysis
alkynes
cross-coupling
tandem reactions
Online Access:https://www.mdpi.com/1420-3049/27/3/630

Internet

https://www.mdpi.com/1420-3049/27/3/630

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