NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults

NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults

Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) cells. Previous work indicates that both granzyme B (GZB) and K (GZK) are increased with age in CD8+ T-cells, and in...

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Bibliographic Details
Main Authors: Chris P. Verschoor, Emilie Picard, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Aging
Subjects:
aging
granzyme B
granzyme K
NK-cells
t-cells
CMV
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2022.1098200/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2022.1098200/full

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