Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk
The detrimental effect of physical inactivity on muscle characteristics are well known. Irisin, an exercise-induced myokine cleaved from membrane protein fibronectin type III domain-containing protein-5 (FNDC5), mediates at least partially the metabolic benefits of exercise. This study aimed to asse...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/7/999 |
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| author | Andrea D’Amuri Juana Maria Sanz Stefano Lazzer Rado Pišot Bostjan Šimunič Gianni Biolo Giovanni Zuliani Mladen Gasparini Marco Narici Bruno Grassi Carlo Reggiani Edoardo Dalla Nora Angelina Passaro |
| author_facet | Andrea D’Amuri Juana Maria Sanz Stefano Lazzer Rado Pišot Bostjan Šimunič Gianni Biolo Giovanni Zuliani Mladen Gasparini Marco Narici Bruno Grassi Carlo Reggiani Edoardo Dalla Nora Angelina Passaro |
| author_sort | Andrea D’Amuri |
| collection | DOAJ |
| description | The detrimental effect of physical inactivity on muscle characteristics are well known. Irisin, an exercise-induced myokine cleaved from membrane protein fibronectin type III domain-containing protein-5 (FNDC5), mediates at least partially the metabolic benefits of exercise. This study aimed to assess the interplay between prolonged inactivity, circulating irisin, muscle performance, muscle fibers characteristics, as well as the FNDC5 gene expression (FNDC5ge) in muscle and adipose tissue among healthy subjects. Twenty-three healthy volunteers were tested before and after 14 days of Bed Rest, (BR). Post-BR circulating levels of irisin significantly increased, whereas body composition, muscle performance, and muscle fiber characteristics deteriorated. Among the subjects achieving the highest post-BR increase of irisin, the lowest reduction in maximal voluntary contraction and specific force of Fiber Slow/1, the highest increase of FNDC5ge in adipose tissue, and no variation of FNDC5ge in skeletal muscle were recorded. Subjects who had the highest FNDC5ge in adipose tissue but not in muscle tissue showed the highest circulating irisin levels and could better withstand the harmful effect of BR. |
| first_indexed | 2024-03-09T03:41:02Z |
| format | Article |
| id | doaj.art-014add40b7f7416d8f8423f8eb566411 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T03:41:02Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-014add40b7f7416d8f8423f8eb5664112023-12-03T14:40:29ZengMDPI AGBiology2079-77372022-06-0111799910.3390/biology11070999Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue CrosstalkAndrea D’Amuri0Juana Maria Sanz1Stefano Lazzer2Rado Pišot3Bostjan Šimunič4Gianni Biolo5Giovanni Zuliani6Mladen Gasparini7Marco Narici8Bruno Grassi9Carlo Reggiani10Edoardo Dalla Nora11Angelina Passaro12Medical Department, University Hospital of Ferrara Arcispedale Sant’Anna, Via A. Moro 8, I-44124 Ferrara, ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, I-44121 Ferrara, ItalyDepartment of Medicine, University of Udine, Piazzale M. Kolbe 4, I-33100 Udine, ItalyInstitute for Kinesiology Research, Science and Research Centre Koper, Garibaldijeva 1, SI-6000 Koper, SloveniaInstitute for Kinesiology Research, Science and Research Centre Koper, Garibaldijeva 1, SI-6000 Koper, SloveniaDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume, 447, I-340149 Trieste, ItalyMedical Department, University Hospital of Ferrara Arcispedale Sant’Anna, Via A. Moro 8, I-44124 Ferrara, ItalyDepartment of Vascular Surgery, Izola General Hospital, Polje 40, SI-6310 Izola-Isola, SloveniaDepartment of Biomedical Sciences, University of Padua, Via Marzolo 3, I-35131 Padua, ItalyDepartment of Medicine, University of Udine, Piazzale M. Kolbe 4, I-33100 Udine, ItalyInstitute for Kinesiology Research, Science and Research Centre Koper, Garibaldijeva 1, SI-6000 Koper, SloveniaMedical Department, University Hospital of Ferrara Arcispedale Sant’Anna, Via A. Moro 8, I-44124 Ferrara, ItalyMedical Department, University Hospital of Ferrara Arcispedale Sant’Anna, Via A. Moro 8, I-44124 Ferrara, ItalyThe detrimental effect of physical inactivity on muscle characteristics are well known. Irisin, an exercise-induced myokine cleaved from membrane protein fibronectin type III domain-containing protein-5 (FNDC5), mediates at least partially the metabolic benefits of exercise. This study aimed to assess the interplay between prolonged inactivity, circulating irisin, muscle performance, muscle fibers characteristics, as well as the FNDC5 gene expression (FNDC5ge) in muscle and adipose tissue among healthy subjects. Twenty-three healthy volunteers were tested before and after 14 days of Bed Rest, (BR). Post-BR circulating levels of irisin significantly increased, whereas body composition, muscle performance, and muscle fiber characteristics deteriorated. Among the subjects achieving the highest post-BR increase of irisin, the lowest reduction in maximal voluntary contraction and specific force of Fiber Slow/1, the highest increase of FNDC5ge in adipose tissue, and no variation of FNDC5ge in skeletal muscle were recorded. Subjects who had the highest FNDC5ge in adipose tissue but not in muscle tissue showed the highest circulating irisin levels and could better withstand the harmful effect of BR.https://www.mdpi.com/2079-7737/11/7/999inactivityFNDC5 gene expressionmyokinessarcopeniamuscle fiber |
| spellingShingle | Andrea D’Amuri Juana Maria Sanz Stefano Lazzer Rado Pišot Bostjan Šimunič Gianni Biolo Giovanni Zuliani Mladen Gasparini Marco Narici Bruno Grassi Carlo Reggiani Edoardo Dalla Nora Angelina Passaro Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk Biology inactivity FNDC5 gene expression myokines sarcopenia muscle fiber |
| title | Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk |
| title_full | Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk |
| title_fullStr | Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk |
| title_full_unstemmed | Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk |
| title_short | Irisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk |
| title_sort | irisin attenuates muscle impairment during bed rest through muscle adipose tissue crosstalk |
| topic | inactivity FNDC5 gene expression myokines sarcopenia muscle fiber |
| url | https://www.mdpi.com/2079-7737/11/7/999 |
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