Identification of novel natural drug candidates against BRAF mutated carcinoma; An integrative in-silico structure-based pharmacophore modeling and virtual screening process

Identification of novel natural drug candidates against BRAF mutated carcinoma; An integrative in-silico structure-based pharmacophore modeling and virtual screening process

The BRAF gene is responsible for transferring signals from outside of the cell to inside of the nucleus by converting a protein namely B-Raf through the RAS/MAPK pathway. This pathway contribute to cell division, proliferation, migration, and apoptotic cell death of human and animal. Mutation in thi...

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Bibliographic Details
Main Authors: F. A. Dain Md Opo, Ahad Amer Alsaiari, Mohammad Habibur Rahman Molla, Md Afsar Ahmed Sumon, Khaled A. Yaghmour, Foysal Ahammad, Farhan Mohammad, Jesus Simal-Gandara
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Chemistry
Subjects:
pharmacophore modeling
virtual screening
molecular docking
molecular dynamics simulation
BRAF
B-Raf
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.986376/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.986376/full

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