Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells

Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells

Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) responsible for Huntington's disease (HD). Thi...

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Bibliographic Details
Main Authors: Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Neurobiology of Disease
Subjects:
Neuronal network
HTT lowering
Huntington disease
Huntingtin
Pluripotent stem cell
Synapse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002304

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http://www.sciencedirect.com/science/article/pii/S0969996124002304

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