Repurposing Simvastatin in Parkinson’s Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the <i>Substantia nigra</i>

Repurposing Simvastatin in Parkinson’s Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the <i>Substantia nigra</i>

Parkinson’s disease is a neurodegenerative disorder characterized by oxidative stress and immune activation in the nigro-striatal pathway. Simvastatin regulates cholesterol metabolism and protects from atherosclerosis disease. Simvastatin-tween 80 was administered 7 days before sterotaxic intrastria...

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Bibliographic Details
Main Authors: Moisés Rubio-Osornio, Carmen T. Goméz-De León, Sergio Montes, Carmen Rubio, Camilo Ríos, Antonio Monroy, Jorge Morales-Montor
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
MPP<sup>+</sup>
neuroinflammation
oxidative stress proinflammatory cytokines
Online Access:https://www.mdpi.com/1422-0067/24/13/10414

Internet

https://www.mdpi.com/1422-0067/24/13/10414

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