Granulomatous interstitial nephritis with CTLA-4 haploinsufficiency: a case report

Granulomatous interstitial nephritis with CTLA-4 haploinsufficiency: a case report

Abstract Background Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential inhibitory regulator of immune activation. CTLA-4 haploinsufficiency is known to be associated with dysregulation of FOXP3+ regulatory T cells, hyperactivation of effector T cells, and lymphocytic infiltration of multiple...

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Bibliographic Details
Main Authors: Kaori Kohatsu, Tomo Suzuki, Madoka Takimoto, Katsuomi Matsui, Akinori Hashiguchi, Junki Koike, Sayuri Shirai
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Nephrology
Subjects:
CTLA-4 haploinsufficiency
Drug-induced interstitial nephritis
Granuloma
Acute kidney injury
Case report
Online Access:https://doi.org/10.1186/s12882-022-02999-x

Internet

https://doi.org/10.1186/s12882-022-02999-x

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