Population pharmacokinetics of primaquine and its metabolites in African males

Population pharmacokinetics of primaquine and its metabolites in African males

Abstract Background Primaquine (PQ) is the prototype 8-aminoquinoline drug, a class which targets gametocytes and hypnozoites. The World Health Organization (WHO) recommends adding a single low dose of primaquine to the standard artemisinin-based combination therapy (ACT) in order to block malaria t...

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Bibliographic Details
Main Authors: Palang Chotsiri, Almahamoudou Mahamar, Halimatou Diawara, Pius S. Fasinu, Kalifa Diarra, Koualy Sanogo, Teun Bousema, Larry A. Walker, Joelle M. Brown, Alassane Dicko, Roly Gosling, Ingrid Chen, Joel Tarning
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Malaria Journal
Subjects:
Primaquine
Carboxy-primaquine
Primaquine carbamoyl-glucuronide
Pharmacokinetics
Nonlinear mixed-effect model
G6PD-deficiency
Online Access:https://doi.org/10.1186/s12936-024-04979-y

Internet

https://doi.org/10.1186/s12936-024-04979-y

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