Intracellular sodium elevation reprograms cardiac metabolism

Intracellular sodium elevation reprograms cardiac metabolism

The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mi...

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Bibliographic Details
Main Authors: Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay, Brett A. O’Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel A. Tennant, William Fuller, Thomas R. Eykyn, Heinrich Taegtmeyer, Michael J. Shattock
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18160-x

Internet

https://doi.org/10.1038/s41467-020-18160-x

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