Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement. Consequently, these therapies provide widespread inhibition of complement pathway activit...

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Bibliographic Details
Main Authors: Kelly C. Fahnoe, Fei Liu, Jennifer G. Morgan, Sarah T. Ryan, Michael Storek, Ellen Garber Stark, Fred R. Taylor, V. Michael Holers, Joshua M. Thurman, Stefan Wawersik, Susan L. Kalled, Shelia M. Violette
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
anti-complement therapy
bifunctional fusion protein
complement negative regulatory protein
tissue targeting
C3d
pharmacodynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.869725/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.869725/full

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