Expression and Function of Transmembrane-4 Superfamily (Tetraspanin) Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis

Expression and Function of Transmembrane-4 Superfamily (Tetraspanin) Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis

Background: Osteoclasts are bone-resorbing multinuclear polykaryons essential for bone remodeling, formed through cell fusion of mononuclear macrophage/monocyte lineage precursor cells upon stimulation by the RANK/RANKL system. Recent studies have revealed that a family of tetraspanin proteins, such...

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Bibliographic Details
Main Authors: Kaori Iwai, Masaru Ishii, Shiro Ohshima, Kunio Miyatake, Yukihiko Saeki
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Allergology International
Subjects:
cell fusion
NET-6
osteoclast
tetraspanin
Tspan-5
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015308959

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http://www.sciencedirect.com/science/article/pii/S1323893015308959

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