Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage—Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities
Philadelphia chromosome (Ph) results from a translocation between the breakpoint cluster region (<i>BCR</i>) gene on chromosome 9 and ABL proto-oncogene 1 (<i>ABL1</i>) gene on chromosome 22. The fusion gene, <i>BCR-ABL1</i>, is a constitutively active tyrosine ki...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/16/5776 |