Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage—Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities

Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage—Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities

Philadelphia chromosome (Ph) results from a translocation between the breakpoint cluster region (<i>BCR</i>) gene on chromosome 9 and ABL proto-oncogene 1 (<i>ABL1</i>) gene on chromosome 22. The fusion gene, <i>BCR-ABL1</i>, is a constitutively active tyrosine ki...

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Bibliographic Details
Main Authors: Lukasz Komorowski, Klaudyna Fidyt, Elżbieta Patkowska, Malgorzata Firczuk
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
leukemia
CML
B-ALL
TKIs
drug targets
p190
Online Access:https://www.mdpi.com/1422-0067/21/16/5776

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