Multi-omic Profiling Reveals that Intra-abdominal-Hypertension-Induced Intestinal Damage Can Be Prevented by Microbiome and Metabolic Modulations with 5-Hydroxyindoleacetic Acid as a Diagnostic Marker

Multi-omic Profiling Reveals that Intra-abdominal-Hypertension-Induced Intestinal Damage Can Be Prevented by Microbiome and Metabolic Modulations with 5-Hydroxyindoleacetic Acid as a Diagnostic Marker

ABSTRACT Emerging evidence shows that modulation of the microbiome can suppress intra-abdominal hypertension (IAH)-induced intestinal barrier damage through the regulation of amino acid (AA) biosynthesis. Here, we investigated the protective effects of orally gavaged Lactobacillus acidophilus L-92 (...

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Bibliographic Details
Main Authors: Fang Li, Liuyiqi Jiang, Shuming Pan, Shaowei Jiang, Yiwen Fan, Chao Jiang, Chengjin Gao, Yuxin Leng
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSystems
Subjects:
intra-abdominal hypertension
sepsis
biomarker
multi-omics
microbiome
tryptophan metabolism
Online Access:https://journals.asm.org/doi/10.1128/msystems.01204-21

Internet

https://journals.asm.org/doi/10.1128/msystems.01204-21

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