Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women

Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women

Abstract Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the associ...

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Bibliographic Details
Main Authors: Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori, Mehrnaz Mehrabani, Saeedeh Salimi
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Biomedical Science
Subjects:
P21
P53
Placenta
Polymorphism
Preeclampsia
Methylation
Online Access:http://link.springer.com/article/10.1186/s12929-019-0586-x

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http://link.springer.com/article/10.1186/s12929-019-0586-x

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