Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Elevated protein synthesis, and dysregulated mGluR signalling, are documented in fragile X syndrome (FXS) Here the authors use proteomic analysis in a mouse model of FXS, and following mGluR5 stimulation, to identify potential biomarkers for the disease.

Bibliographic Details
Main Authors: Heather Bowling, Aditi Bhattacharya, Guoan Zhang, Danyal Alam, Joseph Z. Lebowitz, Nathaniel Bohm-Levine, Derek Lin, Priyangvada Singha, Maggie Mamcarz, Rosemary Puckett, Lili Zhou, Sameer Aryal, Kevin Sharp, Kent Kirshenbaum, Elizabeth Berry-Kravis, Thomas A. Neubert, Eric Klann
Format: Article
Language:English
Published: Nature Portfolio 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09553-8

Internet

https://doi.org/10.1038/s41467-019-09553-8

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