Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach
The work began with the screening of a library of 700,000 small molecules for inhibitors of <i>Trypanosoma brucei </i>growth (a phenotypic screen). The resulting set of 1035 hit compounds was reviewed by a team of medicinal chemists, leading to the nomination of 17 chemically distinct sc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-02-01
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| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/5/1/23 |