Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

Asymmetric division generates cellular diversity by producing daughter cells with different fates. In animals, the mitotic spindle aligns with Par complex polarized fate determinants, ensuring that fate determinant cortical domains are bisected by the cleavage furrow. Here, we investigate the mechan...

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Bibliographic Details
Main Authors: Ognjen Golub, Brett Wee, Rhonda A Newman, Nicole M Paterson, Kenneth E Prehoda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
cell polarity
asymmetric cell division
tumor suppressor
autoinhibition
protein kinase
cell signaling
Online Access:https://elifesciences.org/articles/32137

Internet

https://elifesciences.org/articles/32137

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