Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells

Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells

Neuronal cells are competent in precisely sensing nanotopographical features of their microenvironment. The perceived microenvironmental information will be “interpreted” by mechanotransductive processes and impacts on neuronal functioning and differentiation. Attempts to influence neuronal differen...

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Bibliographic Details
Main Authors: Elisa Maffioli, Carsten Schulte, Simona Nonnis, Francesca Grassi Scalvini, Claudio Piazzoni, Cristina Lenardi, Armando Negri, Paolo Milani, Gabriella Tedeschi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mechanotransduction
integrin signaling
quantitative shot gun proteomics
biophysics
biomaterial
neuronal differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00417/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00417/full

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