Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling

Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling

Context Alantolactone, the bioactive component in Inula helenium L. (Asteraceae), exhibits multiple biological effects. Objective We aimed to determine the anti-inflammatory effect of alantolactone in a collagen-induced arthritis (CIA) mouse model and its immunomodulatory effects on Th17 differentia...

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Bibliographic Details
Main Authors: Hsiang-Lai Chen, Shih Chao Lin, Shiming Li, Kuo-Tung Tang, Chi-Chien Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
inula helenium l.
rorγt
synovial hyperplasia
bone erosion
il-6
il-17a
anti-inflammation
Online Access:http://dx.doi.org/10.1080/13880209.2021.1876102

Internet

http://dx.doi.org/10.1080/13880209.2021.1876102

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