VEGFR Inhibitors for Uterine Metastatic Perivascular Epithelioid Tumors (PEComa) Resistant to mTOR Inhibitors. A Case Report and Review of Literature

VEGFR Inhibitors for Uterine Metastatic Perivascular Epithelioid Tumors (PEComa) Resistant to mTOR Inhibitors. A Case Report and Review of Literature

Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms. PI3K/AKT/mTOR pathway upregulation is critical for their pathogenesis and is often associated with TSC1/TSC2 inactivation. Although first line mTOR inhibitors are an effective treatment, metastatic PEComas eventually progress...

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Bibliographic Details
Main Authors: Aikaterini Liapi, Patrice Mathevet, Fernanda G. Herrera, Delfyne Hastir, Apostolos Sarivalasis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
uterine perivascular epithelioid cell tumor
soft tissue sarcomas
mTOR
second line
VEGFR
PEComa
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.641376/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.641376/full

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