The Histamine H<sub>4</sub> Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A<sub>3</sub> Receptor Agonist IB-MECA: Role of CD4<sup>+</sup> T Cells

The Histamine H<sub>4</sub> Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A<sub>3</sub> Receptor Agonist IB-MECA: Role of CD4<sup>+</sup> T Cells

A<sub>3</sub> adenosine receptor (A<sub>3</sub>AR) agonists have emerged as potent relievers of neuropathic pain by a T cell-mediated production of IL-10. The H<sub>4</sub> histamine receptor (H<sub>4</sub>R), also implicated in pain modulation, is exp...

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Bibliographic Details
Main Authors: Laura Micheli, Mariaconcetta Durante, Elena Lucarini, Silvia Sgambellone, Laura Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomolecules
Subjects:
neuropathic pain
A<sub>3</sub>AR
H<sub>4</sub>R
allodynia
interleukin-10
CD4<sup>+</sup> T cells
Online Access:https://www.mdpi.com/2218-273X/11/10/1447

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https://www.mdpi.com/2218-273X/11/10/1447

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