Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.

Bibliographic Details
Main Authors: Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, Dimitri Titeca-Beauport, Carine Bounaix, Luca Danelli, Pierre Launay, Marc Benhamou, Ulrich Blank, Eric Daugas, Nicolas Charles, Renato C. Monteiro
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00294-0

Internet

https://doi.org/10.1038/s41467-017-00294-0

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