EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contribution to ALS remain incompletely understood. Ast...

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Bibliographic Details
Main Authors: Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V Brown, Nathan T Henderson, Samantha J Thomas, Biswarup Ghosh, Rachel E Cain, Davide Trotti, Piera Pasinelli, Megan C Wright, Matthew B Dalva, Angelo C Lepore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
ALS
astrocyte
motor neuron
ephrin
respiratory
Online Access:https://elifesciences.org/articles/89298

Internet

https://elifesciences.org/articles/89298

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