Prenatal overexpression of platelet‐derived growth factor receptor A results in central nervous system hypomyelination

Prenatal overexpression of platelet‐derived growth factor receptor A results in central nervous system hypomyelination

Abstract Background Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA signaling is downregulated prior to OPC different...

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Bibliographic Details
Main Authors: Herminio Joey Cardona, Agila Somasundaram, Donna M. Crabtree, Samantha L. Gadd, Oren J. Becher
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Brain and Behavior
Subjects:
brain tumors
diffuse midline glioma
hypomyelination
myelination
oligodendrocyte precursor cells
PDGF
Online Access:https://doi.org/10.1002/brb3.2332

Internet

https://doi.org/10.1002/brb3.2332

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