Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

Summary: Chronic kidney disease (CKD) is associated with substantial morbidity and mortality. We developed a mouse model that mimics human CKD with inflammation, extracellular matrix deposition, tubulointerstitial fibrosis, increased proteinuria, and associated reduction in glomerular filtration rat...

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Bibliographic Details
Main Authors: Cuiyan Xin, Jiahui Lei, Qian Wang, Yixia Yin, Xiaoqian Yang, Jose Alberto Moran Guerrero, Venkata Sabbisetti, Xiaoming Sun, Vishal S. Vaidya, Joseph V. Bonventre
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:iScience
Subjects:
Biological sciences
Biochemistry
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221011615

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http://www.sciencedirect.com/science/article/pii/S2589004221011615

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