Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancer

Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancer

Highlights 1. DDS based on cholesterol, ketoester, and NIPAAm, designed for the delivery of DOX. 2. The ketoester and arrangement of blocks are crucial for anticancer activity. 3. PNPs not only act as transporters but also sensitize the cell to DOX. 4. High cytotoxicity of DOX-loaded PNPs was achiev...

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Bibliographic Details
Main Authors: Paweł Misiak, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Przemysław Wielgat, Izabela Kurowska, Robert Czarnomysy, Iwona Misztalewska-Turkowicz, Halina Car, Krzysztof Bielawski, Agnieszka Z. Wilczewska
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cancer Nanotechnology
Subjects:
Polymeric nanoparticles
Cholesterol-end capped poly(N-isopropylacrylamide)
Cell-penetrating molecules
Breast cancer
Doxorubicin
Smart drug delivery systems
Online Access:https://doi.org/10.1186/s12645-023-00176-9

Internet

https://doi.org/10.1186/s12645-023-00176-9

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