A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state

A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state

Summary: The gut metabolite composition determined by the microbiota has paramount impact on gastrointestinal physiology. However, the role that bacterial metabolites play in communicating with host cells during inflammatory diseases is poorly understood. Here, we aim to identify the microbiota-dete...

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Bibliographic Details
Main Authors: Moran Fremder, Seung Won Kim, Ahlam Khamaysi, Liana Shimshilashvili, Hadar Eini-Rider, I Seul Park, Uzi Hadad, Jae Hee Cheon, Ehud Ohana
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
succinate
citrate
ion transport
epithelia
macrophages
microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009529

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http://www.sciencedirect.com/science/article/pii/S2211124721009529

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