Precision Oncology in Lower-Grade Gliomas: Promises and Pitfalls of Therapeutic Strategies Targeting IDH-Mutations

Precision Oncology in Lower-Grade Gliomas: Promises and Pitfalls of Therapeutic Strategies Targeting IDH-Mutations

Mutations in isocitrate dehydrogenase (<i>IDH)1</i> and its homolog <i>IDH2</i> are considered an earliest “driver” genetic event during gliomagenesis, representing now the molecular hallmark of lower-grade gliomas (LGGs). <i>IDH</i>-mutated genes encode for a neo...

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Bibliographic Details
Main Authors: Pasquale Persico, Elena Lorenzi, Agnese Losurdo, Angelo Dipasquale, Antonio Di Muzio, Pierina Navarria, Federico Pessina, Letterio Salvatore Politi, Giuseppe Lombardi, Armando Santoro, Matteo Simonelli
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
isocitrate dehydrogenase (IDH) mutations
lower-grade gliomas
IDH inhibitors
Glioblastoma
clinical trials
targeted therapy
Online Access:https://www.mdpi.com/2072-6694/14/5/1125

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https://www.mdpi.com/2072-6694/14/5/1125

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