ITDetect: a method to detect internal tandem duplication of FMS-like tyrosine kinase (FLT3) from next-generation sequencing data with high sensitivity and clinical application

ITDetect: a method to detect internal tandem duplication of FMS-like tyrosine kinase (FLT3) from next-generation sequencing data with high sensitivity and clinical application

Abstract Internal tandem duplication (ITD) of the FMS-like tyrosine kinase (FLT3) gene is associated with poor clinical outcomes in patients with acute myeloid leukemia. Although recent methods for detecting FLT3-ITD from next-generation sequencing (NGS) data have replaced traditional ITD detection...

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Bibliographic Details
Main Authors: Sungyoung Lee, Choong-Hyun Sun, Heejun Jang, Daeyoon Kim, Sung-Soo Yoon, Youngil Koh, Seung Chan Na, Sung Im Cho, Man Jin Kim, Moon-Woo Seong, Ja Min Byun, Hongseok Yun
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Bioinformatics
Subjects:
Internal tandem duplication
Next-generation sequencing
Acute myeloid leukemia
fragment analysis
Online Access:https://doi.org/10.1186/s12859-023-05173-8

Internet

https://doi.org/10.1186/s12859-023-05173-8

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