Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents

A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-b-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. Among these, compounds 2, 6, 7, and 9 exhibited the...

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Bibliographic Details
Main Authors: Ji-Wang Chern, Sheau Farn Yeh, Lan-Chun Tu, Chia-Ching Liaw, Yao Haur Kuo, Chun-Ling Lin, Yao-To Chang, Ya-Ching Shen
Format: Article
Language:English
Published: MDPI AG 2011-02-01
Series:Marine Drugs
Subjects:
carbazolyl-1,2,3,4-tetrahydro-b-carbolines
carbazolyl-3,4-dihydro-b-carbolines
antitumor agents
structure activity relationship
Online Access:http://www.mdpi.com/1660-3397/9/2/256/

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http://www.mdpi.com/1660-3397/9/2/256/

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