Autophagy Induces Expression of IL-6 in Human Periodontal Ligament Fibroblasts Under Mechanical Load and Overload and Effects Osteoclastogenesis in vitro

Autophagy Induces Expression of IL-6 in Human Periodontal Ligament Fibroblasts Under Mechanical Load and Overload and Effects Osteoclastogenesis in vitro

Objective: Autophagy is an important cellular adaptation mechanism to mechanical stress. In animal experiments, inhibition of autophagy during orthodontic tooth movement triggered increased expression of inflammation-related genes and decreased bone density. The aim of this study was to investigate...

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Bibliographic Details
Main Authors: Alexandra Mayr, Jana Marciniak, Benedikt Eggers, Kim Blawat, Jan Wildenhof, Rogerio Bastos Craveiro, Michael Wolf, James Deschner, Andreas Jäger, Svenja Beisel-Memmert
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
autophagy
cell-cell communication
IL-6
ADAM10
ADAM17
mechanical load
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.716441/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.716441/full

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