Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with distinct fold topologies.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25085-6 |