Exosomal miR-301a-3p from esophageal squamous cell carcinoma cells promotes angiogenesis by inducing M2 polarization of macrophages via the PTEN/PI3K/AKT signaling pathway

Exosomal miR-301a-3p from esophageal squamous cell carcinoma cells promotes angiogenesis by inducing M2 polarization of macrophages via the PTEN/PI3K/AKT signaling pathway

Abstract Background Growing evidence has indicated that tumor-associated macrophages (TAMs) promote tumor angiogenesis. However, the mechanisms underlying the pro-angiogenic switch of TAMs remains unclear. Here, we examined how exosomal miR-301a-3p secreted by esophageal squamous cell carcinoma (ESC...

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Bibliographic Details
Main Authors: Yuwei Shou, Xiaoqian Wang, Chao Chen, Yinghao Liang, Chenbo Yang, Qiankun Xiao, Hui Li, Shuaiyuan Wang, Jiao Shu, Xiangyu Tian, Kuisheng Chen
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cancer Cell International
Subjects:
Exosomes
miR-301a-3p
Macrophage polarization
PI3K/AKT signaling pathway
Angiogenesis
Esophageal squamous cell carcinoma
Online Access:https://doi.org/10.1186/s12935-022-02570-6

Internet

https://doi.org/10.1186/s12935-022-02570-6

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