Secreted frizzled related-protein 2 (Sfrp2) deficiency decreases adult skeletal stem cell function in mice

Secreted frizzled related-protein 2 (Sfrp2) deficiency decreases adult skeletal stem cell function in mice

Abstract In a previous transcriptomic study of human bone marrow stromal cells (BMSCs, also known as bone marrow-derived “mesenchymal stem cells”), SFRP2 was highly over-represented in a subset of multipotent BMSCs (skeletal stem cells, SSCs), which recreate a bone/marrow organ in an in vivo ectopic...

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Bibliographic Details
Main Authors: Luis Fernandez de Castro, Brian J. Sworder, Byron Mui, Kathryn Futrega, Agnes Berendsen, Matthew D. Phillips, Nathan J. Burbach, Natasha Cherman, Sergei Kuznetsov, Yankel Gabet, Kenn Holmbeck, Pamela G. Robey
Format: Article
Language:English
Published: Nature Publishing Group 2021-12-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-021-00169-7

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https://doi.org/10.1038/s41413-021-00169-7

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