Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers

Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers

The steroid hormone ecdysone regulates insect development via its nuclear receptor (the EcR protein), which functions as a ligand-dependent transcription factor. The EcR regulates target gene expression by binding to ecdysone response elements (EcREs) in their promoter or enhancer regions. Its role...

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Bibliographic Details
Main Authors: Dong Cheng, Zhaoming Dong, Ping Lin, Guanwang Shen, Qingyou Xia
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
chromatin regulation
cisregulatory elements
ecdysone receptor
gene transcription
histone modification
Online Access:https://www.mdpi.com/1422-0067/23/18/10791

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https://www.mdpi.com/1422-0067/23/18/10791

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